To improve the research within the other teams at Mech-Sense, we focus on diagnostic tool development as well as customized apparatus. Using different techniques, not commercially available, we aim to develop methods able to measure physiological parameters objectively.
Previous development:
Multi modal probe facilitates acid- , mechanical-, thermal- and electrical-stimulation in one probe in visceral organs
endoFLIP® facilitates geometric representation of sphincters and various hollow organs during distension. It can be used for various organs
Axial force probe facilitates a direct measure of the peristaltic force in the oesophagus. This is in contrast to manometry which measures the radial squeeze developed
Advanced software tracing deformation of organs during mechanical stimulation
Torsion apparatus for examine biomechanical properties of tissue samples
Ongoing development:
Optimizing the endoFLIP probe to measure the very narrow sphincter of Oddi
Developing methods for the multi modal probe to easier measure in duodenum
Advancement in axial force measurements to enable multiple recordings along the catheter
Advancement in combining multi modal probe and endoscope to add visual and possible of biopsies
Staff:
The staffs working in the development group consists of engineers and technicians working as PhD fellows or post docs. Engineering students are often employed on specific projects.
References:
Gravesen FH, Gregersen H, Arendt-Nielsen L, Drewes AM; "Reproducibility of axial force and manometric recordings in the oesophagus during wet and dry swallows", Neurogastroenterol Motil 2009.
Yang J, Liao D, Zhao J, Gregersen H; "Shear modulus of elasticity of the esophagus", Ann Biomed Eng 2004; 32(9):1223-1230.
McMahon BP, Frokjaer JB, Kunwald P, Liao D, Funch-Jensen P, Drewes AM et al.; "The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction", Am J Physiol Gastrointest Liver Physiol 2007; 292(1):G377-G384.
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