The clinical group applies experimental pain models on different patient groups. Both basic studies and drug studies are being conducted.
Previous studies: This group has examined sensitivity and central pain processing in patients with the following diseases:
Erosive gastro-esophageal reflux
Non-erosive gastro-esophageal reflux
Non-cardiac chest pain
Chronic pancreatitis
Ulcerative colitis
Eosinophilic esophagitis
Hepatic encephalopathy
Ongoing research:
Barrett’s esophagus – sensitivity, acid clearance and motility
Chronic pancreatitis – effect of pregabalin on pain, central pain processing
Non-cardiac chest pain – sensitivity and central pain processing
Staff:
The staff working in the clinical group consists of nurses and medical doctors working as PhD fellows or post docs. Medical students are often employed on specific projects.
Main technology used:
multimodal oesophageal and rectal setups
1-128 channel EEG recordings
somatic pain models: heat, deep pressure pain and electricity
Collaborators:
Aarhus University Hospital, Denmark
Sahlgrenska University Hospital, Sweden
Barts and The London School of Medicine and Dentistry, Queen Mary University, United Kingdom
Catholic University of Leuven, Belgium
Key references:
Drewes AM, Reddy H, Pedersen J, Funch-Jensen P, Gregersen H, Arendt-Nielsen L. Multimodal pain stimulations in patients with grade B oesophagitis. Gut 2006;55:926-932.
Drewes AM, Pedersen J, Reddy H, Rasmussen K, Funch-Jensen P, Arendt-Nielsen L, Gregersen H. Central sensitization in patients with non-cardiac chest pain: a clinical experimental study. Scand J Gastroenterol 2006;41:640-649.
Reddy H, Staahl C, Arendt-Nielsen L, Gregersen H, Drewes AM, Funch-Jensen P. Sensory and biomechanical properties of the esophagus in non-erosive reflux disease. Scand J Gastroenterol 2007;42:432-440.
Dimcevski G, Schipper KP, Tage-Jensen U, Funch-Jensen P, Krarup AL, Toft E, Thorsgaard N, Arendt-Nielsen L, Drewes AM. Hypoalgesia to experimental visceral and somatic stimulation in painful chronic pancreatitis. Eur J Gastroenterol Hepatol. 2006 Jul;18(7):755-64.
Krarup AL, Villadsen GE, Mejlgaard E, Olesen SS, Drewes AM, Funch-Jensen P. Acid hypersensitivity in patients with eosinophilic oesophagitis. Scand J Gastroenterol.. [Epub ahead of print]
