Focus Areas of Research
- Evaluation of pharmacological mechanisms and effects in human models of experimental pain.
- Evaluation of analgesic effect in experimental visceral pain models.
- Investigation of biomarkers and surrogate end points in healthy volunteer studies to provide pivotal information on efficacy, dose-response and time-effects of drugs.
The Pharmacology Research Unit is an academically based experienced unit providing expertise and capacity for running experimental pain and pharmacological studies while offering a range of trial-related services. The Pharmacology Research Unit is a combination of a Clinical Research Organization and a Clinical Trial Unit and professionally offers all tasks related to drug trials. The mission of the Pharmacology team is to evaluate and reveal pharmacological mechanisms and effects in models of experimental pain. This is based on qualified selection of reproducible and validated models, assessment and evaluation methods, resulting in high quality drug trials. The first sponsor initiated study was performed in 2003 and therefore the team has great experience in performing such studies. With fully equipped laboratories, the unit can provide safe research with access to healthy volunteers and a variety of patient groups.
- Olesen AE, Olofsen E, Andresen T, Graversen C, Drewes AM, Dahan A. Stochastic Pharmacokinetic-Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia. Anesth Analg. 2015 Nov;121(5):1165-75.
- Olesen AE, Nielsen LM, Larsen IM, Drewes AM. Randomized clinical trial: efficacy and safety of PPC-5650 on experimental esophageal pain and hyperalgesia in healthy volunteers. Scand J Gastroenterol. 2015 Feb;50(2):138-44
- Olesen AE, Brock C, Sverrisdóttir E, Larsen IM, Drewes AM. Sensitivity of quantitative sensory models to morphine analgesia in humans. J Pain Res. 2014 Dec 9;7:717-26.
- Olesen SS, Graversen C, Bouwense SA, van Goor H, Wilder-Smith OH, Drewes AM. Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. PLoS One. 2013;8(3):e57963.
- Olesen AE, Andresen T, Staahl C, Drewes AM. Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs. Pharmacol Rev. 2012 Jul;64(3):722-79.
- Olesen SS, Graversen C, Olesen AE, Frøkjaer JB, Wilder-Smith O, van Goor H, Valeriani M, Drewes AM. Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. Aliment Pharmacol Ther. 2011 Oct;34(8):878-87.
- Andresen T, Staahl C, Oksche A, Mansikka H, Arendt-Nielsen L, Drewes AM. Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain. Br J Pharmacol. 2011 Oct;164(3):934-45
- Olesen SS, Bouwense SA, Wilder-Smith OH, van Goor H, Drewes AM. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology. 2011 Aug;141(2):536-43
- Olesen AE, Staahl C, Arendt-Nielsen L, Drewes AM. Different effects of morphine and oxycodone in experimentally evoked hyperalgesia: a human translational study. Br J Clin Pharmacol. 2010 Aug;70(2):189-200
- Arendt-Nielsen L, Olesen AE, Staahl C, Menzaghi F, Kell S, Wong GY, Drewes AM. Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. Anesthesiology. 2009 Sep;111(3):616-24.